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ASXL1 gene, Somatic mutations in the additional sex comb-like 1 (ASXL1), are involved in the regulation or recruitment of the Polycomb-group repressor complex (PRC) and trithorax-group (trxG) activator complex. Recently, ASXL1 gene profiling has been studied in various types of diseases, which is also considered as a novel marker which may be a risk factor related with the prevalence and prognostic of myelodysplastic syndromes. In addition, more and more studies indicate that ASXL1 mutations may be associated with a poor outcome.
Medaysis Ultra-Sensitive ASXL1 Mutation Detection Kit is a highly specific and sensitive PCR technique that is able to detect common somatic mutations in the ASXL1 gene. Used with Sanger sequencing, it can detect less than 1% (as little as 20 ng to 100 ng of) mutant genes mixed with the wild-type. It is designed to amplify ASXL1 gene from formalin-fixed paraffin-embedded (FFPE) tissues, fresh or frozen tissues, cell smears, fine needle biopsies (FNA) or pleural effusion specimens.
The feature of Medaysis mutation detection kit:
1. Detect known and unknown mutation in target Exons
2. Highly specific and sensitive mutation enrich technology
3. Open system and easy to be done
4. Minimal sample size
5. No microdissection required
| Gene Name | ASXL1 additional sex combs like 1 |
| Catalog | 20 tests: ASXL10001-20; 50 tests: ASXL10001-50 |
| Official Symbol | ASXL1 |
| Alternative Name | ASXL1; additional sex combs like 1; putative Polycomb group protein ASXL1; additional sex combs-like protein 1 |
| GeneID | 55252 |
| Uniprot ID | Q76L83 |
| List of Components | 1. ASXL1 Primer Set 2. ASXL1 Sequencing Primer-R 3. DNA Quality Control Primer Mix 4. 2x PCR Master Mix 5. Nuclease-Free Water |
| Recommended PCR Condition | 95°C, 5mins; 95°C, 30seconds–>59°C, 30seconds–>72°C, 1mins (x45 cycles); 72°C, 10mins°; 10°C, ∞ |
| Platform | PCR + Sanger sequencing assay |
| Shipping Condition | 4°C |
| Long Term Storage | Stable for up to one year when store at -20°C. Avoid freeze/thaw cycles |
| Datasheet | Ultra-Sensitive ASXL1 Mutation Detection Kit |
ASXL1 Mutation Detection Kit
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