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MPL Mutation Detection Kit

​​​​The MPL gene encodes the thrombopoietin receptor protein, which promotes the cell growth and division. Especially, this thrombopoietin receptor is important for the proliferation of megakaryocytes and the maintenance of hematopoietic stem cells within the bone marrow. Mutations of the MPL gene are usually referred to as Exon 10 W515, which have been associated with essential thrombocythemia and primary (idiopathic) myelofibrosis, leading to the overproduction of abnormal megakaryocytes, an increased number of platelets, as well as many signs and symptoms of the condition. (1-3)

Medaysis Ultra-Sensitive MPL Mutation Detection Kit is a highly specific and sensitive PCR technique that is able to detect common somatic mutations in the MPL gene. Used with Sanger sequencing, it can detect less than 1% (as little as 20 ng to 100 ng of) mutant genes mixed with the wild-type (Table 1).  It is designed to amplify MPL gene from formalin-fixed paraffin-embedded (FFPE) tissues, fresh or frozen tissues, cell smears, fine needle biopsies (FNA) or pleural effusion specimens. 

The feature of Medaysis mutation detection kit:
1. Detect known and unknown mutation in target Exons
2. Highly specific and sensitive mutation enrich technology
3. Open system and easy to be done
4. Minimal sample size
5. No microdissection required

info@medaysis.com    Toll Free: 877-524-9167